I have been doing it once a year since ownership (3 times). I cut the mount for the wiring harness a bit so that I can slide it out a bit easier (still a PITA). I suppose it is a little over 15K each time. They have been clear so far but I worry about tank delam. so I am sure to do it each year.
E-350 Super Duty Chateau 6.0 PSD 175,000 miles (Wiring harness relaced (under warrantee), FICM replaced, Alternator, Ball Joints, Motorcraft Batteries (3rd set), Radiator, Tank Delamination and pump, all glow plugs, stabilizer bar ...)
2007 Chevy Express Explorer
1999 Chevy Express Mark III
2013 StarCraft Autumn Ridge 329