Go to
www.me.iastate.edu/biodiesel and click on the online 'course' page and read all 26 pages (I"m not being facetious).
If I remember right, buried in there is a discussion of timing and biodiesel emissions- basically, changing the timing a little can give you even cleaner emissions with biodiesel than it already has, but if youre going back and forth between bio and regular #2 you don't want to do that as you'll pollute more on regular diesel if you retard the timing.
ALso I defer to experts on your truck- I run an ancient 6.9 and it's fine to change the timing on that, I don't know anything aobut your vehicle!
Basically it'll run absolutely fine with no modifications or timing changes, but if you want to be even 'cleaner' with your exhaust and you're only going to run 100% biodiesel, then you can accomplish this in some cars by retarding (I think) the timing. Most people don't do this.
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