From a strictly mechanical stand point, if you have a 4X2 with a fixed flange drive shaft unit, the adapter will accept a transfer case. Like this:
http://www.mrtruck.net/engine6.jpg
Obviously, a shorter driveshaft would be needed, but the location of the transmission mount to the cross member is the same.
If your unit has a slip yoke drive shaft, the output shaft is different, along with the thrust bearing that is in front of the park gear. Need less to say the extension housing would have to be changed as well as the drive shaft, among other things.