You will typically lose about 2 mpg going from 2 wheel drive to 4 wheel drive, and lose another 2 mpg going from single rear wheel to dual rear wheel. The mpg that you are getting with a cc drw 4X4 is as good or better than anyone else is getting. You have upgraded your off road capability, towing and payload, but unfortunately, you have to pay for it by losing some mpg.
2001 F350 XLT 4X4 crew cab, dual rear wheels, long bed, black, 7.3l turbo diesel, automatic transmission, 4.10, shift on the fly, running boards, sliding rear window, 38 gal fuel tank, Odyssey extreme 65-PC1750T batteries, Michelin LTX-MS2 rear tires, Sumitomo Encounter front tires, Shell Rotella Ultra elc, 11,500 gvwr, 20,000 gcwr, 7500 gvw, completely stock, 114,000 miles when purchased, now has 240,000 miles, repairs so far: two starters, batteries, cps, brakes, tires, alternator, ball joints, locking hub, wheel hub, AC compressor, serpentine belt, power steering pump, driver's side window, ignition switch, o-ring, Spectra premium radiator, water pump, fan clutch, fan blades, thermostat, thermostat housing, tensioner. Stolen twice so far, but recovered both times with major damage.
2005 Nomad Rampage toyhauler made by Skyline. 11,500lb gvwr.