In one of my other posts a while back, I had found that the battery cables looked fine on the outside, but when I peeled back the insulation a few inches from the terminal, I found all sorts of wire cancer. I had had an issue with batteries down here only lasting a year to 18 months, and then having to get new batteries. It wasn't until the 4th gyration of getting new batteries ($$$$) that I decided to check the cables. Btw, in that time, I had also changed out the voltage regulator 3 times. After changing out the wire harness 2 years ago, I haven't had any more battery issues. fwiw, it is my opinion that the batteries made now are not nearly as good as the batteries from 10 or 15 years ago. Yes, we run a lot more through those batteries than we used to, but even boat batteries don't last longer than a year or two any more.
I do love my 2000 F250, though. When I bought it in 1999, I sure hadn't planned on keeping it around this long. But, its too good and reliable to consider replacing it now.
just my .02 cents worth
Y2K F250 CC PSD Auto, Short-bed Lariat, Woodland Green/Gold, ordered 07/10/99, born 09/12/99, delivered 10/08/99, Bed mat, Zoodad mod, Viper Remote Start Alarm, Fumoto valve, undercoated, 156k somewhat trouble-free miles (so far), Edge Evolution (60 HP setting), Pioneer DVD/CD/iPod/XM satellite, backup camera, aluminum camper shell to replace the ROLLX that I had on the bed
Repairs: CPS, Water Separator Valve assembly, rear axle bearings, VSS, batteries, brakes, alternator, serpentine belt (x2) and tension pullies, all 4 power lock actuators, water pump, air conditioning lines and compressor, battery cables, replaced the leather oem seat covers with very good leather replacements (found a great place and price from a place in Dallas that custom makes them)
2016 Subaru Outback (Wife's commuter car)
2016 Starcraft Autumn Ridge 29ft TT