Check both front and back. Even though it seems as if it is coming from the back, sometimes it is hard to tell exactly where it is coming from; so check all four corners. Check tires for blebs, bubbles, nails, tread coming loose. Double check all lugnuts. Jack up each wheel and move each wheel side to side and up and down to check for any looseness. Also check behind the front wheels. There are some bolts that hold the wheels on. If those bolts come loose, a wheel may fall completely off.
2001 F350 XLT 4X4 crew cab, dual rear wheels, long bed, black, 7.3l turbo diesel, automatic transmission, 4.10, shift on the fly, running boards, sliding rear window, 38 gal fuel tank, Odyssey extreme 65-PC1750T batteries, Michelin LTX-MS2 rear tires, Sumitomo Encounter front tires, Shell Rotella Ultra elc, 11,500 gvwr, 20,000 gcwr, 7500 gvw, completely stock, 114,000 miles when purchased, now has 240,000 miles, repairs so far: two starters, batteries, cps, brakes, tires, alternator, ball joints, locking hub, wheel hub, AC compressor, serpentine belt, power steering pump, driver's side window, ignition switch, o-ring, Spectra premium radiator, water pump, fan clutch, fan blades, thermostat, thermostat housing, tensioner. Stolen twice so far, but recovered both times with major damage.
2005 Nomad Rampage toyhauler made by Skyline. 11,500lb gvwr.