I don't think there's a real connection between locking hubs and wheel bearing assembly failures. In fact, the spindle bearing that the stub axle runs on inside the wheel hub is NOT turning when the hubs are locked. I run with my hubs (manual) locked all winter, as do many 4x4 drivers here in Alaska, and have done this on many trucks. It's hard on the u-joints, but most of the other parts survive pretty well. The older serviceable wheel bearing styles were harder on the axle stub spindle bearings than the superduty non-serviceable hub/bearing assy, because the axle rotated inside the spindle bearing when in 4x4. With the later hubs, the spindle bearing turns with the wheel, and when in 4x4, the axle and spindle bearing outer race are turning together. It's actually harder on the spindle bearing to run with hubs UNLOCKED.
I think your neighbor's failure was probably just coincidental, although some say that destroyed spindle bearings can cause heat and subsequent failure of the hub/wheel bearing assembly.