I wouldn't bother swapping the fronts, but that's just me. I don't think you'll ever have an issue with wear/reliability, unless you haul an extreme amount of weight 24/7. Most all of your loading will be on the rearend, hence the light steering when you get a good load on.
It should also be a Dana 80. I don't have any experience with F450s, so someone else will chime in who owns one. I just know Ford was the first to put 80s in their vehicles, and they were only originally available in Superduties.
I don't know the width on the axles OR spring perches on the superduties, either. You might have some major fitment issues with putting that in. On the positive side, I do know that a Dodge cab and chassis Dana 80 will fit pretty well in a Ford- ask me how I know. It's only about an inch narrower than the Sterling (about the same as a GM 14-bolt), and you'll have to move the spring perches, but that's no big deal.
If your superduty 80 won't work too well, I'd look to trade it for a dodge cab and chassis 80 (which will also give you your 8-lug wheels).