There are two parts....1st, a tunable product, like SCT will let you get the attributes you want, but keep in mind that the main battle is not the programmer you use....its the wire from your brain to the go pedal. You can take 4-5 MPG off your optimum with a heavy foot. Just try one tank and beat the piss out of it, WOT at almost every light, etc. Then do another tank and really go easy on her. Nice smooth take offs, keep RPMS below 3000 (2500 if you can), build a little speed on down hills, lose a litte on up hills, etc. A bone stock 6.0 will see a large change in these two experiments, which will be more than any tuner can save you.....
Not saying a tuner won't help; it will, but with a heavy foot, a lot of your expected gains will not materialize,
Ralph