I only use my F250 for hauling a travel trailer around the country, and I HATE being broke-down. So I have a lot of gauges and techniques to try to prevent that.
One of my techniques is testing diesel fuel before pumping it into my truck. I do this via an old, heavy one-gallon glass jar that years ago they used for milk deliveries. I squirt about a half-gallon of fuel from the filling station into that jar. Then I look at that sample. If it's suspiciously dark, or if a water bubble forms at the bottom, or if it looks like there's anything but clear, clean diesel in that sample, I put the nozzle back, pay a couple bucks for the suspicious half-gallon and drive away to find a station with better fuel.
It only takes a few seconds for problems to show up in the fuel sample, including and especially enough water to form bubbles at the bottom.
Very rarely is there a problem with diesel fuel. But when there is, it can cause an enormous amount of headaches and damage. I don't want to deal with that on what is supposed to be a fun trip somewhere down the road.