well, the pinion just gets smaller and the ring gear just gets thicker as you go numerically higher. (lower gears)
If you think about it, taller tires put MORE stress on the pinion and ring gear, as the ring gear only moved at tire speed, so.....
4.88 would be about the max for me.
If I ran 44's, sure 5.13 (and take it easy)
my 4.56's are on a 7.3 w/ 40 to 42" tires. The 6.0 is stock (tires and gears)